Thanks for starting this discussion Ron
Personally, I see a few issues with Bootstrap. Primarily my concern is with it's size and usability; it's a toolkit, a very large and complicated one. It isn't really intended to be implemented en masse but rather to provide a selection of tools from which an experienced developer can select that best fitting the job at hand. Secondly, it wasn't intended to be just rolled out as is. Each of it's components are there to provide some default basic styling with the intention that it be customised. If that doesn't happen we simply add to the growing number of 'bootstrappy' clone sitres already in existence.
Is Joomla an awesome standalone CMS, or a platform for implementing bootstrappy sites?
Absolutely no disrespect to Kyle for getting the ball rolling with Bootstrap, but I personally would rather not see Joomla go Bootstrappy, I think it is strong enough to promote an image of it's own. Sure, there are many issues with Joomla's styling, but it is recognisably Joomla. I want it to remain recognisably Joomla.
1. I roll my own, taking what best fits the job from available toolkits if appropriate. This is the approach I would like to see Joomla take. We have some amazingly talented developers, more than enough skill to build a kick-ass toolkit of our own, one that intended to be Joomla from the start and best fits Joomla's requirements.
2. Standards, accessibility (in both senses of the word) and lightness of code.
3. Bootstrap and HTML5BP. I greatly prefer the latter.
4. Anything that includes code you will never use

5. I think we should roll our own. Let's not call it Joomstrap.